abstract：BACKGROUND:A tick-borne segmented RNA virus called Jingmen tick virus (JMTV) was recently identified, variants of which were detected in a non-human primate host and fatal patients with Crimean-Congo haemorrhagic fever. We investigated its infectivity and pathogenicity for humans. METHODS:We obtained skin-biopsy, bloo...

journal_title：EBioMedicine

authors： Jia N,Liu HB,Ni XB,Bell-Sakyi L,Zheng YC,Song JL,Li J,Jiang BG,Wang Q,Sun Y,Wei R,Yuan TT,Xia LY,Chu YL,Wei W,Li LF,Ye JL,Lv QY,Cui XM,Guan Y,Tong YG,Jiang JF,Lam TT,Cao WC

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:A newly developed drug trastuzumab emtansine (T-DM1) has improved the survival of breast cancer (BC) patients. Despite an impressive initial clinical response, a subgroup of patient develop resistance and present therapeutic challenges. The underlying resistance mechanisms are not fully investigated. We repo...

journal_title：EBioMedicine

authors： Islam SS,Uddin M,Noman ASM,Akter H,Dity NJ,Basiruzzman M,Uddin F,Ahsan J,Annoor S,Alaiya AA,Al-Alwan M,Yeger H,Farhat WA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. METHODS:Circulating PDGFRβ levels were analysed in a cohort of patients wi...

journal_title：EBioMedicine

authors： Lambrecht J,Verhulst S,Mannaerts I,Sowa JP,Best J,Canbay A,Reynaert H,van Grunsven LA

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:While PARP inhibitors and CDK4/6 inhibitors, the two classes of FDA-approved agents, have shown promising clinical benefits, there is an urgent need to develop new therapeutic strategies to improve clinical response. Meanwhile, extending the utility of these inhibitors beyond their respective molecularly def...

journal_title：EBioMedicine

authors： Yi J,Liu C,Tao Z,Wang M,Jia Y,Sang X,Shen L,Xue Y,Jiang K,Luo F,Liu P,Cheng H

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Urinary tract infections are known to be caused by bacteria, but the potential implications of archaea have never been studied in this context. METHODS:In two different university hospital centres we used specific laboratory methods for the detection and culture of archaeal methanogens in 383 urine specimen...

journal_title：EBioMedicine

authors： Grine G,Lotte R,Chirio D,Chevalier A,Raoult D,Drancourt M,Ruimy R

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The mitochondrial associated endoplasmic reticulum (ER) membrane (MAM) provides a platform for communication between the mitochondria and ER, and it plays a vital role in many biological functions. Disulphide-bond A oxidoreductase-like protein (DsbA-L), expressed in the MAM, serves as an antioxidant and redu...

journal_title：EBioMedicine

authors： Yang M,Zhao L,Gao P,Zhu X,Han Y,Chen X,Li L,Xiao Y,Wei L,Li C,Xiao L,Yuan S,Liu F,Dong LQ,Kanwar YS,Sun L

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Angiogenesis improves reperfusion to the ischaemic tissue after vascular obstruction. The underlying molecular mechanisms of post-ischaemic angiogenesis are not clear. FAM3A belongs to the family with sequence similarity 3 (FAM3) genes, but its biological function in endothelial cells in regards to vascular ...

journal_title：EBioMedicine

authors： Xu W,Liang M,Zhang Y,Huang K,Wang C

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:The diagnosis of multidrug resistant and extensively drug resistant tuberculosis is a global health priority. Whole genome sequencing of clinical Mycobacterium tuberculosis isolates promises to circumvent the long wait times and limited scope of conventional phenotypic antimicrobial susceptibility, but gaps ...

journal_title：EBioMedicine

authors： Chen ML,Doddi A,Royer J,Freschi L,Schito M,Ezewudo M,Kohane IS,Beam A,Farhat M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Anti-angiogenic treatment failure is often attributed to drug resistance, unsuccessful drug delivery, and tumor heterogeneity. Recent studies have speculated that anti-angiogenic treatments may fail due to characteristics inherent to tumor-associated blood vessels. Tumor-associated blood vessels are phenotyp...

journal_title：EBioMedicine

authors： Jiménez-Torres JA,Virumbrales-Muñoz M,Sung KE,Lee MH,Abel EJ,Beebe DJ

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) are clinically effective in non-small cell lung cancer (NSCLC) patients harbouring epidermal growth factor receptor (EGFR) oncogene mutations. Genetic factors, other than EGFR sensitive mutations, that allow prognosis of TKI treatment remain undefined. METHODS:We retrospect...

journal_title：EBioMedicine

authors： Chen M,Xu Y,Zhao J,Zhong W,Zhang L,Bi Y,Wang M

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Colistin resistance mediated by mcr-1-harbouring plasmids is an emerging threat in Enterobacteriaceae, like Salmonella. Based on its major contribution to the diarrhoea burden, the epidemic state and threat of mcr-1-harbouring Salmonella in community-acquired infections should be estimated. METHODS:This ret...

journal_title：EBioMedicine

authors： Lu X,Zeng M,Xu J,Zhou H,Gu B,Li Z,Jin H,Wang X,Zhang W,Hu Y,Xiao W,Zhu B,Xu X,Kan B

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, the physiological functions of the epigenetic regulators in these processes remain largely elusive. METHODS:Hepatocyte-specific Arid1a knockout mice were administrated with high-fat diet (HFD) fo...

journal_title：EBioMedicine

authors： Qu YL,Deng CH,Luo Q,Shang XY,Wu JX,Shi Y,Wang L,Han ZG

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. METHODS:Patient-derived GBM cells were engineered by CRISPR/Cas9-assisted knock-in of an inducib...

journal_title：EBioMedicine

authors： Tejero R,Huang Y,Katsyv I,Kluge M,Lin JY,Tome-Garcia J,Daviaud N,Wang Y,Zhang B,Tsankova NM,Friedel CC,Zou H,Friedel RH

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least...

journal_title：EBioMedicine

authors： Strawbridge RJ,Ward J,Ferguson A,Graham N,Shaw RJ,Cullen B,Pearsall R,Lyall LM,Johnston KJA,Niedzwiedz CL,Pell JP,Mackay D,Martin JL,Lyall DM,Bailey MES,Smith DJ

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

journal_title：EBioMedicine

authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive study, novel therapeuti...

journal_title：EBioMedicine

authors： Siebenthall KT,Miller CP,Vierstra JD,Mathieu J,Tretiakova M,Reynolds A,Sandstrom R,Rynes E,Haugen E,Johnson A,Nelson J,Bates D,Diegel M,Dunn D,Frerker M,Buckley M,Kaul R,Zheng Y,Himmelfarb J,Ruohola-Baker H,Akiles

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...

journal_title：EBioMedicine

authors： Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibr...

journal_title：EBioMedicine

authors： Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology. Owing to the rapid development of phosphoproteomics, we can now measure thousands of phosphoproteins in human cancer tissues. However, limited studie...

journal_title：EBioMedicine

authors： Tong M,Yu C,Zhan D,Zhang M,Zhen B,Zhu W,Wang Y,Wu C,He F,Qin J,Li T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhe...

journal_title：EBioMedicine

authors： Wen Q,Jiao X,Kuang F,Hou B,Zhu Y,Guo W,Sun G,Ba Y,Yu D,Wang D,Zhang F,Qiao HC,Wang S,Tang S,Qiao H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat...

journal_title：EBioMedicine

authors： Huang R,Hu Z,Cao Y,Li H,Zhang H,Su W,Xu Y,Liang L,Melgiri ND,Jiang L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:We aimed to identify a magnetic resonance imaging (MRI)-based model for assessment of the risk of individual distant metastasis (DM) before initial treatment of nasopharyngeal carcinoma (NPC). METHODS:This retrospective cohort analysis included 176 patients with NPC. Using the PyRadiomics platform, we extra...

journal_title：EBioMedicine

authors： Zhang L,Dong D,Li H,Tian J,Ouyang F,Mo X,Zhang B,Luo X,Lian Z,Pei S,Dong Y,Huang W,Liang C,Liu J,Zhang S

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Acute lung injury (ALI) is a severe life-threatening inflammatory disease. Neutrophil activation is a major pathogenic factor in ALI. Protein kinase B (PKB)/AKT regulates diverse cellular responses, but the significance in neutrophilic inflammation and ALI remains unknown. METHODS:Human neutrophils and neut...

journal_title：EBioMedicine

authors： Chen PJ,Ko IL,Lee CL,Hu HC,Chang FR,Wu YC,Leu YL,Wu CC,Lin CY,Pan CY,Tsai YF,Hwang TL

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. METHODS:Glycoengineered cell lines were...

journal_title：EBioMedicine

authors： Freitas D,Campos D,Gomes J,Pinto F,Macedo JA,Matos R,Mereiter S,Pinto MT,Polónia A,Gartner F,Magalhães A,Reis CA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

journal_title：EBioMedicine

authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

更新日期：2019-02-01 00:00:00

abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

journal_title：EBioMedicine

authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials. Acetyl-11-keto-β-boswellic acid (AKBA) is the most bioactive ingredient of boswellic aci...

journal_title：EBioMedicine

authors： Bai J,Gao Y,Chen L,Yin Q,Lou F,Wang Z,Xu Z,Zhou H,Li Q,Cai W,Sun Y,Niu L,Wang H,Wei Z,Lu S,Zhou A,Zhang J,Wang H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. METHODS:Deci...

journal_title：EBioMedicine

authors： Huang J,Xue M,Zhang J,Yu H,Gu Y,Du M,Ye W,Wan B,Jin M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Decidual natural killer (dNK) cells are the predominant lymphocytes accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in preeclampsia, a gestational complication characterized by high blood pressure and increased proteinuria occurring after 20 weeks pregnancy, is not completely u...

journal_title：EBioMedicine

authors： Zhang J,Dunk CE,Shynlova O,Caniggia I,Lye SJ

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated splicing deregulation both as molecular prognostic factor and potential ...

journal_title：EBioMedicine

authors： Sciarrillo R,Wojtuszkiewicz A,El Hassouni B,Funel N,Gandellini P,Lagerweij T,Buonamici S,Blijlevens M,Zeeuw van der Laan EA,Zaffaroni N,Deraco M,Kusamura S,Würdinger T,Peters GJ,Molthoff CFM,Jansen G,Kaspers GJL,Cloos J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Several studies have reported microRNAs (miRNAs) could regulate the placental development, though the role and mechanism of miRNAs in the development of non-diabetic macrosomia (NDFMS) remains unclear. METHODS:To identify the aberrantly expressed key miRNAs in placenta of NDFMS, we employed a strategy consi...

journal_title：EBioMedicine

authors： Guo D,Jiang H,Chen Y,Yang J,Fu Z,Li J,Han X,Wu X,Xia Y,Wang X,Chen L,Tang Q,Wu W

更新日期：2018-12-01 00:00:00

abstract：:Trauma experienced during surgery can contribute to the development of a systemic inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis. Vari...

journal_title：EBioMedicine

authors： Alam A,Hana Z,Jin Z,Suen KC,Ma D

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Hepatocyte is particularly vulnerable to apoptosis, a hallmark of many liver diseases. Although pro-apoptotic mechanisms have been extensively explored, less is known about the hepatocyte-specific anti-apoptotic molecular events and it lacks effective approach to combat hepatocyte apoptosis. We investigated ...

journal_title：EBioMedicine

authors： Wang H,Ge C,Zhou J,Guo Y,Cui S,Huang N,Yan T,Cao L,Che Y,Zheng Q,Zheng X,Gonzalez FJ,Wang G,Hao H

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Epidemiological, laboratory and clinical studies have established an association between elevated urate and high blood pressure (BP). However, the inference of causality remains controversial. A naturally occurring antioxidant, urate may also be neuroprotective, and urate-elevating treatment with its precurs...

journal_title：EBioMedicine

authors： Chen X,Umeh CC,Tainsh RE,Feng DD,Maguire M,Zuo F,Rahimian M,Logan R,Wang X,Ascherio A,Macklin EA,Buys ES,Schwarzschild MA,Parkinson Study Group (PSG) The Safety of Urate Elevation in Parkinson's Disease (SURE-PD) investigators.

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS:Development of the no...

journal_title：EBioMedicine

authors： Qu A,Yang Y,Zhang X,Wang W,Liu Y,Zheng G,Du L,Wang C

更新日期：2018-11-01 00:00:00

abstract：:Rabbits (Oryctolagus cuniculus) have been the very frequently used as animal models in the study of human lipid metabolism and atherosclerosis, because they have similar lipoprotein metabolism to humans. Most of hyperlipidemia and atherosclerosis rabbit models are produced by feeding rabbits a high-cholesterol diet. G...

journal_title：EBioMedicine

authors： Lu R,Yuan T,Wang Y,Zhang T,Yuan Y,Wu D,Zhou M,He Z,Lu Y,Chen Y,Fan J,Liang J,Cheng Y

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC. METHODS:This study included 238 consecutive patients with eyelid SC. All eligible patients were ...

journal_title：EBioMedicine

authors： Zhou C,Shi Y,Chai P,Wu F,Xia W,He X,Shi Y,Huang H,Jia R,Fan X

更新日期：2018-10-01 00:00:00

abstract：:In this thought commentary, I highlight the discoveries made by Seto and colleagues related to HDAC11 and obesity. I discuss how their reported work fills a gap in the HDAC field and comment on the clinical implications of their findings. Overall, selective inhibition of HDAC11 could be a novel potential therapeutic a...

journal_title：EBioMedicine

authors： Bhaskara S

更新日期：2018-09-01 00:00:00

abstract：:Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...

journal_title：EBioMedicine

authors： Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

更新日期：2018-09-01 00:00:00

abstract：:Detecting circulating tumor cells (CTCs) has proven valuable for evaluating the prognosis of cancer patients and for studying the mechanisms of treatment resistance. Owing to the lack of universal and specific tumor markers for neuroblastoma (NB), in this prospective study, we adopted an EpCAM-independent method to de...

journal_title：EBioMedicine

authors： Liu X,Zhang Z,Zhang B,Zheng Y,Zheng C,Liu B,Zheng S,Dong K,Dong R

更新日期：2018-09-01 00:00:00